![]() Colors from Brewer (2013).ĭistribution of individuals in each age class by immune status. The height of the bars in the top row indicates the total proportion in each age class while the bottom row is normalized by age group. (Column (B)) Colors represent the level of symptoms and transmissibility: severe symptoms and full transmissibility I 1 (red), moderate symptoms and transmissibility I 2 (orange), mild symptoms and low transmissibility I 3 (yellow), and neither symptoms nor transmissibility I 4 (light blue). (Column (A)) Colors represent the level of susceptibility: fully susceptible S 1 (red), low partial immunity S 2 (orange), medium partial immunity S 3 (yellow), vaccinated immunity S 4 (light blue), and complete immunity S 5 (blue). The proportion of susceptible (A) or infected (B) individuals from the total population of each status with no vaccination (A1)-(B1), with primary vaccination alone (A2)-(B2), with primary vaccination plus one booster dose (A3)-(B3), with primary vaccination plus two booster doses (A4)-(B4). All rights reserved.ĭistribution of individuals in each age class by immune status. Because pertussis comprises a spectrum of symptoms, only the most severe of which are medically attended, accurate models are needed to design optimal vaccination programs where surveillance is less effective.Īge- and immunity-structured population Immuno-epidemiology Mathematical epidemiology Vaccination Waning and boosting of immunity.Ĭopyright © 2020 The Authors. As one example, we compare simulations with the experience of Sweden following resumption of pertussis vaccination after the hiatus from 1979 to 1996, reproducing the observations leading health authorities to introduce booster doses among school-aged children and adolescents in 20, respectively. The resurgences of pertussis that have been observed wherever effective vaccination programs have reduced typical disease among young children follow from these processes. ![]() We also model age, which affects contact, vaccination and possibly waning rates. We quantify these phenomena in a model population composed of individuals whose susceptibility, infectiousness, and symptoms all vary with immune status. ![]() Symptoms, and concomitantly infectiousness, depend on residual immunity. We offer 30+ full- and part-time programs in a variety of online, face-to-face and blended formats – all designed for professional and international students.Immunity following natural infection or immunization may wane, increasing susceptibility to infection with time since infection or vaccination. Study how human behavior relates to society, why people behave as they do, how they interact with each other and their environment and how they change. SBS explores all about people, past and present. ![]() Your work will help people live in healthy, safe and sustainable communities. Science & MathematicsĮxplore the world through a scientific lens to create solutions to modern problems. By studying humanities, you'll be prepared to lead in a global, inclusive world. Learn to think critically with a grounding in diversity, equity and justice issues. Serve your community as a health advocate, nurse, exercise physiologist, audiologist, environmental health specialist, youth counselor, hospitality & tourism specialist, food scientist, physical therapist, assistive technology specialist and more. Learn the skills to enhance, enrich and empower the human experience. You'll contribute to a variety of business fields with industry-ready skills. Harness the power of data and engineering to create new solutions for our world. Our degree and credential programs will equip you to become a teacher, counselor or administrator. Eisner College of Educationīe prepared to make a difference in the lives of students. You'll tap into our world-class faculty and large alumni network to grow your career. Learn business skills and ethical principles to become a leader in our diverse world. David Nazarian College of Business and Economics From music to theatre to journalism, you'll hone your skills to make a difference in the world. Mike Curb College of Arts, Media, & Communicationĭevelop your passion for art, performance and communication. Learn about their specialties and find the one that interests you most. At CSUN, we have nine colleges that offer a variety of degree and certificate programs.
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